Inert gas washout and HRCT in CF 0. MULTIPLE-BREATH INERT GAS WASHOUT AND SPIROMETRY VS. STRUCTURAL LUNG DISEASE IN CYSTIC FIBROSIS
نویسندگان
چکیده
AFFILIATIONS: 1. Queens Silvia Children’s Hospital, Göteborg, and Department of Pediatrics, The Sahlgrenska Academy at Göteborg, Sweden. 2. Erasmus Medical CenterSophia Children’s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, the Netherlands. 3. Meander Medical Center, Department of Radiology, Amersfoort, the Netherlands. 4. University Medical Center Utrecht, Department of Radiology, Utrecht, the Netherlands.
منابع مشابه
Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis.
Many children with cystic fibrosis (CF), receiving modern, aggressive CF care, have normal spirometry results. This study aimed to see if homogeneity of ventilation distribution is impaired early in the course of CF lung disease, and if ventilation inhomogeneity is a more frequent finding than abnormal spirometry in children benefiting from modern CF care. The study compared spirometry findings...
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BACKGROUND A sensitive and valid non-invasive marker of early cystic fibrosis (CF) lung disease is sought. The lung clearance index (LCI) from multiple-breath washout (MBW) is known to detect abnormal lung function more readily than spirometry in children and teenagers with CF, but its relationship to structural lung abnormalities is unknown. A study was undertaken to determine the agreements b...
متن کاملConsensus statement on inert gas washout measurement: at the threshold of clinical use.
I nert gas washout tests including single breath washout (SBW) and multiple breath washout (MBW) have been used for several decades across a wide age range spanning from early infancy to late adulthood. In the past, these lung function tests were typically applied in research settings, assessing lung volume and ventilation distribution in order to gain insight into presence, severity and progre...
متن کاملLung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF.
RATIONALE High resolution computed tomography (HRCT) is a more sensitive tool for detecting early cystic fibrosis (CF) lung disease than either spirometry or plain radiography, but its relationship to other measures of lung function has not been established in young children. OBJECTIVES (1) To assess whether the lung clearance index (LCI) derived from multiple breath inert-gas washout (MBW) i...
متن کاملCYSTIC FIBROSIS Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis
Background: Multiple breath inert gas washout (MBW) has been suggested as a tool for detecting early cystic fibrosis (CF) lung disease. A study was undertaken to compare the relative sensitivity of MBW and spirometry for detecting abnormal lung function in school age children with CF and to compare MBW results obtained from healthy children in the UK with those recently reported from Sweden. Me...
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